Development and Validation of a Grading Scale for Primary Pontine Hemorrhage

doi:10.1161/STROKEAHA.116.015326

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	Development and Validation of a Grading Scale for Primary Pontine Hemorrhage
	Huang, KB; Ji, Z; Sun, LH; Gao, XY; Lin, SP; Liu, T; Xie, SF; Zhang, QS; Xian, WC; Zhou, SJ
刊名	STROKE
	2017-01
卷号	48 期号:1 页码:63+
关键词	Glasgow Coma Scale intracerebral hemorrhage outcome and process assessment primary pontine hemorrhage prognosis
ISSN号	0039-2499
DOI	10.1161/STROKEAHA.116.015326
文献子类	Article
英文摘要	Background and Purpose-We aimed to develop and validate a grading scale for predicting 30-day mortality and 90-day functional outcome in patients with primary pontine hemorrhage (PPH). Methods-We retrospectively reviewed records of consecutive patients with first-ever pontine hemorrhage from 3 teaching hospitals between 2005 and 2012. Independent factors associated with 30-day mortality were identified by logistic regression to establish a risk stratification scale, named the new PPH score. For validation of the new PPH score, we prospectively recruited subjects from 10 units between December 2014 and November 2015. The performance of the new PPH score was presented as discrimination and calibration, measured by area under the curve of the receiver operating characteristic and Hosmer-Lemeshow goodness-of-fit, respectively. Results-Data of 171 patients were available for scale development. The new PPH score consisted of 2 independent factors with individual points assigned as follows: Glasgow Coma Scale score 3 to 4 (=2 points), 5 to 7 (=1 point), and 8 to 15 (=0 point); PPH volume >10 mL (=2 points), 5 to 10 mL (=1 point), and <5 mL (=0 point). An independent cohort of 98 patients was applied as an external validation of the new PPH score. Results showed that the new PPH score was discriminative in predicting both 30-day mortality (area under the curve, 0.902) and 90-day good outcome (area under the curve, 0.927). Furthermore, the new PPH score revealed a good calibration (chi(2)=1.387; P=0.846) in 30-day mortality prediction. Conclusions-The new PPH score is simple and reliable in predicting short-term and long-term outcome for PPH patients.
学科主题	Neurosciences & Neurology ; Cardiovascular System & Cardiology
出版地	PHILADELPHIA
资助项目	国家自然科学基金项目
项目编号	National Natural Science Foundation of China [81271521, 81471339]
语种	英语
WOS记录号	WOS:000391944900015
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188643]
专题	第一临床医学院_期刊论文
通讯作者	Pan, SY (reprint author), Soouthern Med Univ, Nanfang Hosp, Dept Neurol, Guangzhou 510515, Guangdong, Peoples R China.
推荐引用方式 GB/T 7714	Huang, KB,Ji, Z,Sun, LH,et al. Development and Validation of a Grading Scale for Primary Pontine Hemorrhage[J]. STROKE,2017,48(1):63+.
APA	Huang, KB.,Ji, Z.,Sun, LH.,Gao, XY.,Lin, SP.,...&Pan, SY .(2017).Development and Validation of a Grading Scale for Primary Pontine Hemorrhage.STROKE,48(1),63+.
MLA	Huang, KB,et al."Development and Validation of a Grading Scale for Primary Pontine Hemorrhage".STROKE 48.1(2017):63+.