Cerebrovascular reactivity among native-raised high altitude residents: an fMRI study

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	Cerebrovascular reactivity among native-raised high altitude residents: an fMRI study
	Yan, Xiaodan ; Zhang, Jiaxing ; Gong, Qiyong ; Weng, Xuchu ; Zhang JX(张家兴)
刊名	http://dx.doi.org/10.1186/1471-2202-12-94
	2011-09-26
关键词	ANTERIOR CINGULATE CORTEX FLIGHT MR-ANGIOGRAPHY FUNCTIONAL CONNECTIVITY COGNITIVE CONTROL CHRONIC HYPOXIA BOLD FMRI CEREBRAL AUTOREGULATION NETWORK ANALYSIS ERROR-DETECTION INSULAR CORTEX
英文摘要	National Science Foundation of China [30425008, 60628101, 31071041]; Chinese Ministry of Science and Technology [2007CB512300]; Background: The impact of long term residence on high altitude (HA) on human brain has raised concern among researchers in recent years. This study investigated the cerebrovascular reactivity among native-born high altitude (HA) residents as compared to native sea level (SL) residents. The two groups were matched on the ancestral line, ages, gender ratios, and education levels. A visual cue guided maximum inspiration task with brief breath holding was performed by all the subjects while Blood-Oxygenation-Level-Dependent (BOLD) functional Magnetic Resonance Imaging (fMRI) data were acquired from them. Results: Compared to SL controls, the HA group showed generally decreased cerebrovascular reactivity and longer delay in hemodynamic response. Clusters showing significant differences in the former aspect were located at the bilateral primary motor cortex, the right somatosensory association cortex, the right thalamus and the right caudate, the bilateral precuneus, the right cingulate gyrus and the right posterior cingulate cortex, as well as the left fusiform gyrus and the right lingual cortex; clusters showing significant differences in the latter aspect were located at the precuneus, the insula, the superior frontal and temporal gyrus, the somatosensory cortex (the postcentral gyrus) and the cerebellar tonsil. Inspiratory reserve volume (IRV), which is an important aspect of pulmonary function, demonstrated significant correlation with the amount of BOLD signal change in multiple brain regions, particularly at the bilateral insula among the HA group. Conclusions: Native-born HA residents generally showed reduced cerebrovascular reactivity as demonstrated in the hemodynamic response during a visual cue guided maximum inspiration task conducted with BOLD-fMRI. This effect was particularly manifested among brain regions that are typically involved in cerebral modulation of respiration.
语种	英语
出版者	BMC NEUROSCI
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93231]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Yan, Xiaodan,Zhang, Jiaxing,Gong, Qiyong,et al. Cerebrovascular reactivity among native-raised high altitude residents: an fMRI study[J]. http://dx.doi.org/10.1186/1471-2202-12-94,2011.
APA	Yan, Xiaodan,Zhang, Jiaxing,Gong, Qiyong,Weng, Xuchu,&张家兴.(2011).Cerebrovascular reactivity among native-raised high altitude residents: an fMRI study.http://dx.doi.org/10.1186/1471-2202-12-94.
MLA	Yan, Xiaodan,et al."Cerebrovascular reactivity among native-raised high altitude residents: an fMRI study".http://dx.doi.org/10.1186/1471-2202-12-94 (2011).