| CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5 | |
| LinShuyong ; WangJifeng ; YeZhiyun ; IpNancyY ; LinSheng-Cai ; Lin SC(林圣彩) | |
| 2008 | |
| Keyword | p35 E-cadherin CDK5 lysosomal degradation |
| English Abstract | Dysfunction of E-cadherins often results in metastasis of cancerous cells. Here we show that p35, a critical regulator of cyclin-dependent kinase 5 (CDK5), specifically depletes the precursor form of E-cadherin, but not the mature form, by using a precursor-specific antibody. Most intriguingly, this downregulation of precursor E-cadherin by p35 is unequivocally independent of CDK5. Moreover, we found that p35 forms complexes with E-cadherin proteins. We also found that p35 co-expression can target E-cadherin to lysosomes and that p35-triggered disappearance of E-cadherin precursor can be blocked specifically by lysosomal protease inhibitors, indicating that p35 induces endocytosis and subsequent degradation of precursor E-cadherin. |
| Language | 英语 |
| Content Type | 期刊论文 |
| 源URL | [http://dspace.xmu.edu.cn/handle/2288/6338]  |
| Collection | 生命科学－已发表论文 |
| Recommended Citation GB/T 7714 | LinShuyong,WangJifeng,YeZhiyun,et al. CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5[J],2008. |
| APA | LinShuyong,WangJifeng,YeZhiyun,IpNancyY,LinSheng-Cai,&林圣彩.(2008).CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5.. |
| MLA | LinShuyong,et al."CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5".(2008). |
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