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CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5
LinShuyong ; WangJifeng ; YeZhiyun ; IpNancyY ; LinSheng-Cai ; Lin SC(林圣彩)
2008
关键词p35 E-cadherin CDK5 lysosomal degradation
英文摘要Dysfunction of E-cadherins often results in metastasis of cancerous cells. Here we show that p35, a critical regulator of cyclin-dependent kinase 5 (CDK5), specifically depletes the precursor form of E-cadherin, but not the mature form, by using a precursor-specific antibody. Most intriguingly, this downregulation of precursor E-cadherin by p35 is unequivocally independent of CDK5. Moreover, we found that p35 forms complexes with E-cadherin proteins. We also found that p35 co-expression can target E-cadherin to lysosomes and that p35-triggered disappearance of E-cadherin precursor can be blocked specifically by lysosomal protease inhibitors, indicating that p35 induces endocytosis and subsequent degradation of precursor E-cadherin.
语种英语
内容类型期刊论文
源URL[http://dspace.xmu.edu.cn/handle/2288/6338]  
专题生命科学-已发表论文
推荐引用方式
GB/T 7714
LinShuyong,WangJifeng,YeZhiyun,et al. CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5[J],2008.
APA LinShuyong,WangJifeng,YeZhiyun,IpNancyY,LinSheng-Cai,&林圣彩.(2008).CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5..
MLA LinShuyong,et al."CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5".(2008).
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