Xenopus Claudin-6 is required for embryonic pronephros morphogenesis and terminal differentiation

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	Xenopus Claudin-6 is required for embryonic pronephros morphogenesis and terminal differentiation
	Sun J 1,2; Wang XL 1,2; Li CC 1; Mao BY[*]1
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2015
卷号	462 期号:3 页码:178-183
关键词	Claudin-6 Xenopus Pronephros Morphogenesis Differentiation Tight junction
通讯作者	mao@mail.kiz.ac.cn
合作状况	其它
英文摘要	Claudins are tetratransmembrane tight junction proteins and play important roles in regulating paracellular permeability of different nephron segments of the kidney. However, the roles of claudins in kidney development remain largely unknown. Here we studied the expression and functions of claudin-6 in Xenopus pronephros development. Xenopus claudin-6 is expressed in the developing pronephric tubule and duct but not glomus. Knockdown of claudin-6 by specific morpholino led to severe defects in pronephros tubular morphogenesis and blocked the terminal differentiation of the tubule cells. The claudin-6 morpholino targeted tubule cells showed failure of apical accumulation of actin and reduced lateral expression of tight junction protein Na/K-ATPase, suggesting an incomplete epithelization likely due to defected cell adhesions and apical-lateral polarity. Our work uncovered a novel role for claudin-6 in embryonic kidney development.
收录类别	SCI
资助信息	This work was supported by a grant from the National Natural Science Foundation of China (31271566).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9169]
专题	昆明动物研究所_发育生物学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650203, China
推荐引用方式 GB/T 7714	Sun J,Wang XL,Li CC,et al. Xenopus Claudin-6 is required for embryonic pronephros morphogenesis and terminal differentiation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,462(3):178-183.
APA	Sun J,Wang XL,Li CC,&Mao BY[*].(2015).Xenopus Claudin-6 is required for embryonic pronephros morphogenesis and terminal differentiation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,462(3),178-183.
MLA	Sun J,et al."Xenopus Claudin-6 is required for embryonic pronephros morphogenesis and terminal differentiation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 462.3(2015):178-183.