Target-oriented design and biosynthesis of thiostrepton-derived thiopeptide antibiotics with improved pharmaceutical properties

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	Target-oriented design and biosynthesis of thiostrepton-derived thiopeptide antibiotics with improved pharmaceutical properties
	Wang SF(王守峰)1; Zheng QF(郑庆飞)1; Wang JF(王建峰)1; Zhao ZX(赵志雄)1; Li QY(李庆业)1; Yu YS(俞云松)1; Wang RX(王任小)1; Liu W(刘文)1
刊名	Org. Chem. Front.
	2015
卷号	2 期号:2 页码:106-109
其他题名	以靶点为导向的设计和生物合成获取药理活性更好的硫链丝菌素结构衍生物
通讯作者	刘文
英文摘要	Thiostrepton is a potent archetypal thiopeptide antibiotic. According to its mechanism known to target bacterial ribosome, we show here a rational design upon modeling of this molecule into the ribosome complex and an effective biosynthesis of new thiopeptide antibiotics through regioselective modifications. The resulting derivatives exhibit a series of anticipated and unanticipated pharmaceutical advantages, including improvement in activity against a number of drug-resistant pathogens and in water solubility that has largely affected the clinical use of thiostrepton.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1039/c4qo00288a
语种	英语
WOS记录号	WOS:000364443200002
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/39537]
专题	上海有机化学研究所_生命有机化学国家重点实验室
作者单位	1.中科院上海有机化学研究所, 生命有机化学国家重点实验室 2.浙江大学 3.湖州生物制造创新中心
推荐引用方式 GB/T 7714	Wang SF,Zheng QF,Wang JF,et al. Target-oriented design and biosynthesis of thiostrepton-derived thiopeptide antibiotics with improved pharmaceutical properties[J]. Org. Chem. Front.,2015,2(2):106-109.
APA	王守峰.,郑庆飞.,王建峰.,赵志雄.,李庆业.,...&刘文.(2015).Target-oriented design and biosynthesis of thiostrepton-derived thiopeptide antibiotics with improved pharmaceutical properties.Org. Chem. Front.,2(2),106-109.
MLA	王守峰,et al."Target-oriented design and biosynthesis of thiostrepton-derived thiopeptide antibiotics with improved pharmaceutical properties".Org. Chem. Front. 2.2(2015):106-109.